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Search Results for " chronic constipation "

11

Compounds

Cat No. Product Name Synonyms Targets
T9080 Plecanatide Guanylate cyclase
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T2542 Prucalopride R-93877 5-HT Receptor
Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.
T16083 Mizagliflozin GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base SGLT
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca...
T11852 Linaclotide Guanylate cyclase
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
T6307 Lubiprostone SPI-0211,RU-0211 Chloride channel
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
T15209 Elobixibat AZD 7806,A 3309 Others
Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation.
T28512 Relenopride hydrochloride YKP-10811,YKP10811,YKP 10811,Relenopride HCl
Relenopride, a 5-HT agonist, is used potentially for the treatment of chronic constipation.
T11852L Linaclotide acetate MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775
Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.
T35046 Velusetrag TD 5108,TD5108,TD-5108
Velusetrag(TD-5108)is an effective, selective, and highly potent agonist of the 5-HT4 receptor, and being developed for the treatment of gastroparesis, chronic constipation, and irritable bowel syndrome.
T62973 DS-3801b
DS-3801b is a potent, non-macrolide GPR38 agonist and has the potential to be a novel gastrointestinal agonist for the study of functional gastrointestinal disorders (e.g. gastroparesis, chronic constipation).
T72515 Elobixibat hydrate A 3309 hydrate ; AZD 7806 hydrate,AZD 7806 hydrate,A 3309 hydrate
Elobixibat hydrate, a potent inhibitor of the ileal bile acid transporter (IBAT), exhibits IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human, mouse, and canine IBAT, respectively. It is utilized i...
TargetMol