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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9080 | Plecanatide | Guanylate cyclase | |
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist. | |||
T2542 | Prucalopride | R-93877 | 5-HT Receptor |
Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes. | |||
T16083 | Mizagliflozin | GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base | SGLT |
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... | |||
T11852 | Linaclotide | Guanylate cyclase | |
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist. | |||
T6307 | Lubiprostone | SPI-0211,RU-0211 | Chloride channel |
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation. | |||
T15209 | Elobixibat | AZD 7806,A 3309 | Others |
Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation. | |||
T28512 | Relenopride hydrochloride | YKP-10811,YKP10811,YKP 10811,Relenopride HCl | |
Relenopride, a 5-HT agonist, is used potentially for the treatment of chronic constipation. | |||
T11852L | Linaclotide acetate | MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775 | |
Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. | |||
T35046 | Velusetrag | TD 5108,TD5108,TD-5108 | |
Velusetrag(TD-5108)is an effective, selective, and highly potent agonist of the 5-HT4 receptor, and being developed for the treatment of gastroparesis, chronic constipation, and irritable bowel syndrome. | |||
T62973 | DS-3801b | ||
DS-3801b is a potent, non-macrolide GPR38 agonist and has the potential to be a novel gastrointestinal agonist for the study of functional gastrointestinal disorders (e.g. gastroparesis, chronic constipation). | |||
T72515 | Elobixibat hydrate | A 3309 hydrate ; AZD 7806 hydrate,AZD 7806 hydrate,A 3309 hydrate | |
Elobixibat hydrate, a potent inhibitor of the ileal bile acid transporter (IBAT), exhibits IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human, mouse, and canine IBAT, respectively. It is utilized i... |